It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health. XLZ and JNL will assess the risk of bias and perform data synthesis. Les capsules Lianhua Qingwen sont les produits phares de Yiling Pharmaceutical pour le traitement de maladies spcifiques comme le rhume, la grippe et la COVID-19. An official website of the United States government. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. Used in the patterns of heat toxin assailing the lung in influenza, manifested as fever or high fever, aversion to cold, muscular soreness, stuffy and runny nose, cough, headache, dry and sore throat, reddish tongue, yellow or yellow and greasy tongue coating. TheChinese researchers also claim thatLHQWisa classical Chinese medical preparation and that itscapsules or granulesareconsist of 11 herbs, gypsum,and mentholwhich are recorded in the2015 Edition ofthe ChinesePharmacopoeia. Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. Infants / children aged below 4 years are not recommended to consume. In 2008, Diagnosis and Treatment Scheme for Patients Infected with Avian Influenza (2008), issued by the Ministry of Health Before the evaluation results of this system are published, all databases will be retrieved again. 2023 Jan 12;17:11779322221149622. doi: 10.1177/11779322221149622. [31]. A: Chest radiograph of normal people; B: Chest radiograph of a. Lianhua Qingwen Capsule - Yiling Web[Administration and Dosage] For oral administration, 4 capsules once, 3 times a day. Third, the capsule can shorten fever & coughting time. Pregnancy & lactation. The conclusion of this review will provide evidence to judge whether Lianhua Qingwen combined with Conventional antiviral Western Medicine is an effective and safe intervention for COVID-19. National Key New Product Lianhua Qingwen (LHQW), a Chinese supplement approved by thePhilippine Food and Drug Administration (FDA) for mild Covid-19 symptoms,continues togain popularity and controversy. If you buy two boxes at a time, or an integral multiple of two boxes (such as 4 boxes or 6 boxes), we will give you one box for every two boxes. Press the space key then arrow keys to make a selection. "It's the first time in the world that we have enough evidence to prove Lianhua Qingwen Jiaonang capsule is effective and can help patients recover," Zhong said, adding they have just finished an experiment and the results are promising and werepublished. Middle East respiratory syndrome case diagnosis and treatment program (2015 Edition) [J]. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. For patients showing mild symptoms, Lianhua Qingwen would be more effective. Preliminary study on the inhibitory effect of three traditional Chinese medicine prescriptions on SARS related coronavirus in vitro [J]. < 5 years: not recommended because it may be difficult for young children to swallow capsules. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. 2011. In 2010, Diagnosis and Treatment Scheme for Wind-warm Lung-heat Disease (Non-severe Community Acquired Pneumonia) (2010), issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine government site. It has a wide-spectrum antiviral, effective antibacterial, antipyretic and anti-inflammatory, antitussive and expectorant, immune-regulating and other systemic intervention functions,[1625] especially for the coronavirus SARS[26] And Middle East respiratory syndrome (MERS)[27] have significant inhibitory and killing effects. Children, pregnant women, nursing mother, senile and infirm patients or those with week spleen should take medicine under doctors direction. Consumption Directions: Recommended daily intake: 3 times daily. [Packaging] Aluminum plastic plate packaging, 24 capsules / box, 400 boxes / case, Listed in National Essential Drug List [2]. Data synthesis reports the intervention effect of the original study by integrating the cohort study. Evid Based Complement Alternat Med. Unable to load your collection due to an error, Unable to load your delegates due to an error. [Contraindications]Those who are allergic to this product and its ingredients should not take it. Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials. It contains 13 herbs that are anti-viral and anti-inflammatory. In PubMed, MEDLINE, and EMBASE, search with Lianhua Qingwen and COVID-19 as subject words. Chinese Journal of basic medicine of traditional Chinese medicine 2013;19:11335. Chinese drug Lianhua Qingwen is one of 3 treatments which are part of Chinas standard therapy for mild and moderate coronavirus patients. All reports of the randomized controlled trials (RCTs) on Lianhua Qingwen capsule treating influenza Efficacy and safety of Lian-Hua Qing-Wen granule for 2022 Jan;20(1):26-33. doi: 10.1016/j.joim.2021.10.005. A trial of lopinavirritonavir in adults hospitalized with severe. Guyatt GH, Oxman AD, Vist GE, et al. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. [24]. DC and QZ developed the search strategy. [3] It is reported that 4,430,100 cases have been confirmed in the world, and 299,451 cases have died. Chinese herbal medicine 2008;31:12303. [2] The main manifestations of the disease are fever, fatigue, and dry cough. You may search for similar articles that contain these same keywords or you may JAMA Intern Med 2020;March 13 (Epub ahead of print). In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Lianhua Qingwen Patients diagnosed with COVID-19 of all ages and racial groups will be included. Go and see the doctor if the symptom is not alleviated 3 days after administration. Just because a supplement is derived from natural sources does not mean it is safe. In China, lianhua qingwen is recommended for treating thepneumonia. sharing sensitive information, make sure youre on a federal This site needs JavaScript to work properly. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as Two reviewers (XLZ and JNL) will assess the eligibility of the studies retrieved during the searches independently using the inclusion and exclusion criteria. Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology[32] will be used to assess the quality of the evidence and risk of bias with on-line GRADE (https://www.gradeworkinggroup.org/). MANILA, Philippines The Makati Medical Centers therapeutics and medication safety committee (TMSC) has said that the Chinese drug, Lianhua Qingwen (LQ), should not be taken without a doctors prescription to ease new coronavirus disease (COVID-19) symptoms, warning that it may do more harm than good. Copyright 2023 MIMS Pte Ltd. All rights reserved. >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). The clinical effective rate, CT improvement rate, and severe conversion rate will be assessed as the primary outcomes. 9. High-tech Demonstration Project of National Development and Reform Commission Disclaimer. [25]. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. [Adverse Reactions]Post-marketing monitoring data show that this product may cause gastrointestinal adverse reactions such as nausea, vomiting, abdominal pain, diarrhea, bloating, as well as rash, itchy ulcers, dry mouth, dizziness. Correspondence: Mingjun Liu, and Xiaolin Zhang, professor, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jingyue Economic Development Zone, Changchun City, Jilin Province 130117, China (e-mail: [emailprotected], [emailprotected]). WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba 94d329df351d7da8aefc2.shtml, https: //www.who.int/docs/default source/coronaviruse/situation-reports/20200325-sitrep-65-, https://www.jiyinzaixian.com/news/bNu5eb13ba6806e0, http://www.xinhuanet.com/politics/2020-03/24/c_1125757251.htm, http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. Treatment efficacy of Lianhua Qingwen capsules for eraly-stage Now. Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. Hongying Mo, Zifeng Yang, Jinping Zheng, et al. Chinese Journal of pharmacology and toxicology 2015;29:2137. Race to find. Efficacy and safety of Lianhua Qingwen combined with : Medicine For more information, please refer to our Privacy Policy. It has important clinical significance for alleviating the severity of COVID-19 and shortening the course of disease. Do not use this product if the property changed. Lianhua Qingwen (LHQW) However, this systematic review will have some limitations. Asia's one-stop resource for medical news, clinical reference and education, Click to view Lianhua Qingwen detailed prescribing information. [59] In the early stage, there is no specific medicine or vaccine; the intervention of Chinese traditional medicine compound Lianhua Qingwen and other traditional Chinese medicine have played an important role. Post code: 050035 Tel: 0086-311-85901643 Fax: 0086-311-85906730 Website: http://www.yiling.cn Any questions or problems, please do not hesitate to contact manufacturer. Lianhua Qingwen | Yiliang Lianhua Qingwen Jiaonang It is reported that the registration number of Lianhua Qingwen Capsules in the Philippines is THPR-50 and the product category is traditional herbal drugs. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment course. The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. to maintaining your privacy and will not share your personal information without 2.Its not appropriate to take nourishing chinese medicine wihte taking medicine. The full text of articles potentially suitable for the review will be obtained for further assessing eligibility based on the inclusion criteria or/and exclusion criteria. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. If I2 test 50%, a random-effects model will be used for data analysis instead. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. In 2017, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (Version 1)(2017) , issued by the National Health and Family Planning Commission The COVID-19 may improve the clinical symptoms associated with fever, cough, and fatigue. [32]. For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. Lianhua Qingwen, which was approved by China Food and Drug Administration (CFDA) in 2004, was the first traditional Chinese medicine that entered the rapid drug approval channel of the CFDA and was used to prevent severe acute respiratory syndrome (SARS). Use left/right arrows to navigate the slideshow or swipe left/right if using a mobile device. In WANFANG, novel coronavirus pneumonia, 2019-nCOV, COVID-19, and SARS-COV-2 were first searched for the keywords, then searched for the theme word Lianhua Qingwen and Lianhua Qingke. The 2 search were merged with the relationship. Novel coronavirus pneumonia is being set up by CNKI for the new research project. Avoid alcohol and tobacco and spicy,cold, greasy food during taking this product. Dont take this medicine if the description has changed. Consult with doctors or pharmacists before administration if other medicines are received during this time. MJL will arbitrate any disagreement and ensure that no errors occur during the review. Data is temporarily unavailable. Add your comment to start the conversation. Patients with hypertension or heart disease should use with caution, patients with chronic disease such as diabetes, liver disease, kidney disease should take medicine under doctors direction. The two groups were compared in terms of clinical effects and main symptom (fever, cough and fatigue) disappearance rate. FDA Director General Eric Domingo likewise confirmed the approval of Lianhua Qingwen in a text message to Rappler on Wednesday afternoon. The Authors. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. Wang DC, Yu M, Xie WX, Huang LY, Wei J, Lei YH. 1. We may also contact the original authors to provide additional relevant information, if necessary. [15]. Zhongguo Zhong Yao Za Zhi. may email you for journal alerts and information, but is committed In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. It is approved by HSA asan over-the-counter traditional Chinese medicine to treat influenza and colds. China's top respiratory expert,the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. LHQW is approved by China'sNational TCM Administration for the treatment of mild covid-19. [1]. [36]. It is compatible with Rhodiola to clear lung and remove blood stasis. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. 4. patients: total number and number in both groups, baseline characteristics, diagnostic criteria, withdrawals, and losses to follow-up (reasons, description); 5. outcomes: outcomes specified above, adverse drug reactions, and adverse time, length of follow-up, quality of reporting of outcomes. Here are links to the publications that published the results of the clinical trial :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229744/https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtmlIngredients & ContradicationsPlease refer to the pictures for more informationUSAGE FOR RESPIRATORY DISEASES SUCH AS FLUS AND COLDSProphylaxis: If you know you are going out, take LHQW the day before, the day of the outing and the day after the outing. Careers. Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. Bookshelf It has become a representative Chinese patent medicine for public health emergencies of the respiratory system. [1] Over 200 countries and regions in the world have reported the confirmed cases successively, and become the global fast spread pandemic. This product is capsule, brown to yellowish brown particles and powder inside;smell slightly fragrant, slightly bitter taste. Wang Y, Zhang D, Du G, et al. Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. http://creativecommons.org/licenses/by/4.0. Heart or thyroid disease, high BP, diabetes, glaucoma, HTN, tumor of adrenal gland, difficulty in urination due to the enlargement of the prostate gland. Novel coronavirus pneumonia is a new method for the treatment of new crown pneumonia. For novel coronavirus pneumonia, the total effective rate of TCM is over 90%.[EB/OL]. [Overview of Meta-analysis of Lianhua Qingwen preparations in treatment of viral diseases]. Zhong said that, according to the experiment,the Lianhua Qingwen Jiaonang capsule can weakly inhibit the virus and repair cell injuries and inflammation caused by the virus. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. 10. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. It cannot be bought over-the-counter and not recommended for self-medication. All data generated or analyzed during this study are included in this published article [and its supplementary information files]. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. Ding Y, Zeng L, Li R, et al. Also excluded are studies enrolling <30 participants. Before Kunming: Kunming University of technology; 2015. Drug discoveries & therapeutics 2020;14:6772. Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. Biotechnology communication 2003;14:3902. One box of LHQW last 2 days and 4 boxes last 8 days. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. [1014] Data showed that novel coronavirus pneumonia was confirmed in China, and 74,187 people used Chinese medicine, accounting for 91.5%, of which 61,449 in Hubei Province used Chinese medicine, accounting for 90.6%. Conclusion: [Administration and Dosage] Efficacy and safety of herbal medicine (Lianhuaqingwen) for Avoid receiving nourishing Chinese medicine during the period in this product. 7. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in Announcement of the national health and Health Commission of the people's Republic of China [EB /OL] (2020-01-20) [20200217]. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. For oral administration, 4 capsules once, 3 times a day. Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. Philippines FDA approved LHQW for the treatment of mild Covid-19. [Manufacturer]Company name: Shijiazhuang Yiling Pharmaceutical Co., Ltd. Articles in Google Scholar by Xiaolin Zhang, MD, Other articles in this journal by Xiaolin Zhang, MD, Intermediate dose cytarabine improves survival and relapse-free rate compared with standard-dose cytarabine as post-remission treatment for acute myeloid leukemia: A retrospection study, Privacy Policy (Updated December 15, 2022). Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. The https:// ensures that you are connecting to the - China reported 11 new infections of the coronavirus on March 14, and for the first time since the start of the epidemic the majority of them were imported cases from overseas. 10 High heterogeneity may also arise from the various evaluations. FREE SHIPPING within SG when you buy 4 boxes or more. XLZ conceived of the study, and perform this review. How Lianhua Qingwen Jiaonang Capsule Help You All the prescriptions are used to clear the toxic heat in the lung, clear the lung qi, and cut off the disease. Is there any notice for taking Lianhua Qingwen Capsules? Search for Similar Articles Keyword Highlighting The FDA had earlier put out an advisory in May warning against the purchase of unregistered versions of the Lianhua Qingwen Jiaonang capsule which had different labels. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. Pharmacology and clinical research of traditional Chinese medicine 2010;26:214. Chinese Journal of experimental pharmacology 2015;21:13943. Study on the anti Staphylococcus aureus biofilm formation of Lianhuaqingwen capsule [J]. Lianhua Qingwen Capsules can significantly improve the total effective rate for COVID-19 patients, as well as shorten the hospital stay and treatment time, which is worth of promotion in the clinic. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. WebDrug Name Lianhua Qingwen Capsules; Approval No. GYZZ Z20040063; Strength 0.35g/capsule; Administration and Dosage For oral administration, 4 capsules once, 3 Identification of a Pharmacological Biomarker We will judge the each domain as low risk of bias, high risk of bias," or uncertain risk of bias" according to Higgins (2011), and pay particular attention to the risk of bias of cluster-randomised trials. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in the control group (n=33). Records from databases and other resources will be uploaded to a database created by EndNote9.7 software. Select all eligible studies published before May 8, 2020. There are no comments yet. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. After determining how to combine different types of studies, NRIs use the method of inverse variance of random-effect model to evaluate and calculate the 95% CI of the effect value. The composition of Lianhua Qingwen granules is consistent with the pathogenesis of the disease. Some notable dangerous reactions include heart attacks, strokes, seizures, and sudden deaths. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as part of its standard coronavirus treatments. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. Qi Luo Lun [M]. WhileDDB notes the FDAs approvalofLHQWas a traditional herbal product that may helprelievefever, muscle soreness, stuffy and runny nose associated with Covid-19, the DDBalsobelievesinpreventing diversion and unsafe use and abuseof this product withouthampering theaccess toit. Sign in to listen to groundbreaking journalism. Lianhua Qingwen 13. Lianhua Qingwen Dosage & Drug Information | MIMS Philippines Since all the data included are published, the systematic review does not need ethical approval. World Healthy Organization. Ends on 31 July 2022. [8]. The flow diagram of this systematic review is shown in Figure 1. [29]. Please be informed that only the The following electronic bibliographic databases will be searched to identify relevant studies: CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as China Clinical Trial Registration Center (ChiCTR), Netherlands National Trial Registration Center (NTR) and clinical trials.gov. 2022 Aug;47(16):4505-4516. doi: 10.19540/j.cnki.cjcmm.20220510.501. The .gov means its official. Chest radiographs. Teresa May Bandiola is a licensed pharmacist, a published writer, and a university instructor. Consultancy by Fixx Digital STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. The Chinese embassy in the Philippines announced this on Wednesday, August 12, hailing it as an important progress in the entry of TCM products into the Philippine market.. WebChronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory response that is worsened by acute exacerbations.
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